Mouse Anti-SOX9 Monoclonal Antibody (CBP6760)

Description

The development of the central nervous system includes the development of the brain, spinal cord, optic nerve and auditory system. In the neural tube, stem cells produce two major types The cells that make up most of the nervous system: neurons and glia. Both types of cells differentiate into many different types with highly specialized functions and shapes. The development of the peripheral and central nervous system begins in the early stages of embryogenesis and can be tracked by using lineage antibodies specific to each stage of neuron development. The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. [provided by RefSeq, Jul 2008]

Epitope

Binds to an located within the peptide sequence SQRTHIKTEQLSPSH

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a

Clone Number

CBP6760

Applications

IHC; WB; IF

Application Notes

IHC: 1:500-1:1000
WB: 1 µg/ml
IF: 2-10 µg/ml

Research Areas

Growth and Development

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

1 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

SOX9

Official Name

SOX9

Full Name

SRY-Box 9

Alternative Names

SRY-Box 9; Campomelic Dysplasia; Autosomal Sex-Reversal; SRY (Sex-Determining Region Y)-Box 9 Protein; SRY (Sex Determining Region Y)-Box 9; SRY (Sex Determining Region Y)-Box9; SRY-Related HMG-Box; Gene 9; Transcription Factor SOX-9

Gene ID

6662(Human); 20682(Mouse); 140586(Rat)

Uniprot ID

P48436(Human); Q04887(Mouse)