NeuroMab™ Anti-GABA-A-R-Alpha1 BBB Shuttle Antibody, Clone N95/35

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GABA A Receptor Alpha 1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 355-394 (cytoplasmic loop) of human GABA-A-RAlpha1 (also known as Gamma-aminobutyric acid receptor subunit alpha-1, accession number P14867)
Mouse: 100% identity (40/40 amino acids identical)
Rat: 100% identity (40/40 amino acids identical)
<50% identity with GABA-A-R-Alpha2

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N95/35

Applications

WB; IHC; ICC

Application Notes

No cross-reactivity against GABA-A-R-Alpha2

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

GABA A Receptor Alpha 1

Official Name

GABRA1

Full Name

GABA(A)R, Alpha1

Alternative Names

GABRA1; ECA4; EIEE19; EJM; EJM5; gamma-aminobutyric acid type A receptor alpha1 subunit; gamma-aminobutyric acid type A receptor subunit alpha1

Uniprot ID

P14867

Product Pictures

Fig. 1 Immunoblot of adult mouse membranes from wild-type (WT) and GABA-A-R-Alpha1 knockout (KO) mice probed with N95/35 (green) and anti-actin polyclonal (red).