NeuroMab™ Anti-GABA-A-R-Alpha1 BBB Shuttle Antibody, Clone N95/35
[CAT#: NRZP-0423-ZP109]
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; IHC; ICC
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GABA A Receptor Alpha 1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 355-394 (cytoplasmic loop) of human GABA-A-RAlpha1 (also known as Gamma-aminobutyric acid receptor subunit alpha-1, accession number P14867)
Mouse: 100% identity (40/40 amino acids identical)
Rat: 100% identity (40/40 amino acids identical)
<50% identity with GABA-A-R-Alpha2
Mouse: 100% identity (40/40 amino acids identical)
Rat: 100% identity (40/40 amino acids identical)
<50% identity with GABA-A-R-Alpha2
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Human; Mouse; Rat
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
N95/35
Applications
WB; IHC; ICC
Application Notes
No cross-reactivity against GABA-A-R-Alpha2
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
GABA A Receptor Alpha 1
Official Name
GABRA1
Full Name
GABA(A)R, Alpha1
Alternative Names
GABRA1; ECA4; EIEE19; EJM; EJM5; gamma-aminobutyric acid type A receptor alpha1 subunit; gamma-aminobutyric acid type A receptor subunit alpha1
Uniprot ID
P14867
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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