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Creative Biolabs

NeuroMab™ Anti-Tau Antibody(NRP-0422-P1761)

[CAT#: NRP-0422-P1761]

Functional antibody against Human Tau

Host Species:
Mouse
Species Reactivity:
Human
Applications:
WB; ELISA; In Vitro; In Vivo

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Product Overview

Description

The monoclonal antibody binds to the tau truncated Asp421 epitope, useful in the diagnosis and treatment of tau abnormalities.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

WB; ELISA; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease
Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

> 95% (SDS-PAGE)

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only
Target

Target

Tau

Official Name

Tau

Full Name

Tau

Alternative Names

CD14

Gene ID

4137(Human); 17762(Mouse); 29477(Rat)

Uniprot ID

P10636(Human); P10637(Mouse); P19332(Rat)
Product Pictures
FuncS

Figure 1 shows the abbreviated tau for antibodies at 1:1000, 1:3000, 1:9000, 1:27000 and 1:81000 antibody dilutions. Immunospecificity for the Asp421 epitope is shown.

FuncS

Figure 2 shows mixed cortical cultures of JNPL3 mice pretreated with PHF (1 μg/ml) against antibody 5G2A3 and antibody 1G11A10 (10 μg/ml) over time.

FuncS

Figure 3 shows mixed cortical cultures of JNPL3 mice pretreated with PHF (1 μg/ml) against antibody 5G2A3 and antibody 1G11A10 (10 μg/ml) over time.

FuncS

Figure 4 Effect of immunospecific binding of antibody to truncated tau Asp421 epitope.

FuncS

Figure 5 Significant reductions in Iba1 levels were observed at 72 and 96 h in mixed cortical cultures treated with antibody 5G2A3 compared to cells treated with control and PHF only.

FuncS

Figure 6 Effect of antibodies that can bind mixed neuronal cultures.

FuncS

Figure 7 Co-incubation of antibody 1G11A10 antibody with PHF failed to demonstrate any significant changes in phospho-tau levels compared to cells treated with PHF alone and PHF + IgG at all time points.

FuncS

Figure 8 Among antibodies 5G2A3 and 1G11A10, only antibody 5G2A3 was found to effectively reduce total tau levels.

FuncS

Figure 9 Co-incubation of antibody 5G2A3 with PHF did not reveal any significant change in Iba1 levels compared to untreated control cells, whereas a significant increase in Iba1 levels was observed in PHF only, PHF + IgG and cells treated with PHF + Antibody 1G11A10.

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