NeuroMab™ Anti-TrpV3 cation channel BBB Shuttle Antibody, Clone N15/39

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-TRPV3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 774-791 (C-terminus) of rat TrpV3 (KTTLYAFDELDEFPETSV; NP_001020928)
Human: 77% identity (14/18 amino acids identical)
Mouse=100% identity (18/18 amino acids identical)
Common to all TrpV3 splice variants

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N15/39

Applications

WB; IHC; IP; ICC

Research Areas

Trp channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

TRPV3

Official Name

TRPV3

Full Name

TrpV3

Alternative Names

Transient Receptor Potential Cation Channel Subfamily V Member 3

Uniprot ID

NP_0010209

Product Pictures

Fig. 1 Transfected HEK293 cell immunofluorescence staining N15/39=green, DAPI=blue.

Fig. 2 Transfected cell immunoblot. Extracts of COS-1 cells transiently transfected with rat TrpV3 (left lane) or rat Kv2.1 (right lane) plasmids and probed with K89/34 TC supe (left panel) or pure N15/4 (right panel).

Publications