NeuroMab™ Anti-Amyloid Beta 1-5 BBB Shuttle Antibody(NRZP-1022-ZP3644)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Chimeric

Applications

WB; ELISA; In Vitro

Relevant Diseases

Alzheimer's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

AmyloidBeta1-5

Official Name

Amyloid Beta

Full Name

Amyloid Beta

Alternative Names

Aβ; Abeta

Product Pictures

ELISA

Figure 1 illustrates the Aβ binding properties of 3D6, chimeric 3D6 and 10D5.

Figure 1A is a graph depicting the binding of Aβ to chimeric 3D6 (PK1614) compared to murine 3D6.

ELISA

Figure 1 illustrates the Aβ binding properties of 3D6, chimeric 3D6 and 10D5.

Figure 1B is a graph depicting the competition of biotinylated 3D6 with unlabeled 3D6, PK1614 and 10D5 for Aβ binding.

ELISA

Figure 2 illustrates the Aβ binding properties of chimeric 3D6 and humanized 3D6.

Figure 2A depicts the results of an ELISA measuring the binding of humanized 3D6v1 and chimeric 3D6 to aggregated Aβ.

ELISA

Figure 2 illustrates the Aβ binding properties of chimeric 3D6 and humanized 3D6.

Figure 2B depicts the results of an ELISA measuring the binding of humanized 3D6v1 and humanized 3D6v2 to aggregated Aβ.

FuncS

Figure 3 is a graph quantifying the binding of humanized 3D6 and chimeric 3D6 to Aβ plaques from PDAPP mouse brain sections.

FuncS

Figure 4 is a graph showing the results of a competitive binding assay testing the ability of humanized 3D6 versions 1 and 2, chimeric 3D6, murine 3D6 and 10D5 to compete with murine 3D6 for binding to Aβ.

FuncS

Figure 5 illustrates an ex vivo phagocytosis assay testing the ability of humanized 3D6v2, chimeric 3D6, and human IgG to mediate Aβ uptake by microglia.

Publications