NeuroMab™ Anti-ASIC1 BBB Shuttle Antibody, Clone N271/44

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-ASIC1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 460-526 (cytoplasmic C-terminus) of mouse ASIC1 (also known as Acidsensing ion channel 1, Neuronal amiloride-sensitive cation channel 2, Brain sodium channel 2, BNaC2 and Accn2, accession number Q6NXK8)
Rat: 98% identity (66/67 amino acids identical)
Human: 97% identity (65/67 amino acids identical)
100% identity between ASIC1a and ASIC1b
<40% identity with ASIC2, ASIC3 or ASIC4

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N271/44

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with ASIC2

Research Areas

Ion channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

ASIC1

Official Name

ASIC1

Full Name

ASIC1

Alternative Names

ASIC1; ACCN2; ASIC; BNaC2; Acid sensing ion channel subunit 1

Uniprot ID

Q6NXK8

Product Pictures

Fig. 1 Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged ASIC1, ASIC2 or untagged Kv2.1 plasmid and probed with N271/44 (left) or N86/8 (right) TC supe.