NeuroMab™ Anti-ASIC1 BBB Shuttle Antibody, Clone N271/44
[CAT#: NRZP-0423-ZP30]
- Species Reactivity:
- Mouse; Rat
- Applications:
- WB; IHC; ICC
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-ASIC1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 460-526 (cytoplasmic C-terminus) of mouse ASIC1 (also known as Acidsensing ion channel 1, Neuronal amiloride-sensitive cation channel 2, Brain sodium channel 2, BNaC2 and Accn2, accession number Q6NXK8)
Rat: 98% identity (66/67 amino acids identical)
Human: 97% identity (65/67 amino acids identical)
100% identity between ASIC1a and ASIC1b
<40% identity with ASIC2, ASIC3 or ASIC4
Rat: 98% identity (66/67 amino acids identical)
Human: 97% identity (65/67 amino acids identical)
100% identity between ASIC1a and ASIC1b
<40% identity with ASIC2, ASIC3 or ASIC4
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Mouse; Rat
Clonality
Monoclonal
Isotype
IgG1
Clone Number
N271/44
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with ASIC2
Research Areas
Ion channels
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
ASIC1
Official Name
ASIC1
Full Name
ASIC1
Alternative Names
ASIC1; ACCN2; ASIC; BNaC2; Acid sensing ion channel subunit 1
Uniprot ID
Q6NXK8
Publications
Publications (0)
Neural Antibodies
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
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