NeuroMab™ Anti-Kv4.2 potassium channel (external) BBB Shuttle Antibody, Clone K57/1

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCND2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 209-225 (CGSSPGHIKELPSGERY, extracellular S1-S2 loop, where third Ser was substituted in place of a Cys for peptide conjugation purposes) of human Kv4.2 (Potassium voltage-gated channel subfamily D member 2, Voltage-gated potassium channel subunit Kv4.2, Kcnd2, Kiaa1044, MNCb-7013, RK5 and Shal1, accession number Q9NZV8)
Rat: 100% identity (17/17 amino acids identical)
Mouse: 100% identity (17/17 amino acids identical)
>75% identity with Kv4.3

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

K57/1

Applications

WB; IHC; IP; ICC

Application Notes

Does not cross-react with Kv4.3

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCND2

Official Name

KCND2

Full Name

Kv4.2 K+ channel (external)

Alternative Names

KCND2; KV4.2; RK5; potassium voltage-gated channel subfamily D member 2

Uniprot ID

Q9NZV8

Product Pictures

Fig. 1 Immunoblot against crude brain membranes from adult rat (RBM) and wild-type (MBM-WT) and Kv4.2 knockout (MBM-Kv4.2-KO) mice probed with K57/1 (left) or K89/41 (right) TC supe.

Fig. 2 Immunoblot against crude C. elegans worm extracts and RBM.

Fig. 3 Immunoblot against crude membranes from whole mouse (MBM) or rat (RBM) brain and from human cerebellum [HBM(Cb)], cerebral cortex [HBM(Cx)] or hippocampus [HBM(H)] and probed with K57/1 (left) or N52A/42 loading control (right) TC supe.