NeuroMab™ Anti-Kv4.2 potassium channel subunit BBB Shuttle Antibody, Clone L28/4
[CAT#: NRZP-0423-ZP224]
- Species Reactivity:
- Human; Rat; Mouse
- Applications:
- WB; IHC; ICC
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCND2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 471-630 (cytoplasmic C-terminus) of rat Kv4.2 (Potassium voltage-gated channel subfamily D member 2, Voltage-gated potassium channel subunit Kv4.2, Kcnd2, Kiaa1044, MNCb-7013, RK5 and Shal1, accession number Q63881)
Mouse: 99% identity (159/160 amino acids identical)
Human: 98% identity (157/160 amino acids identical)
<50% identity with Kv4.3
Mouse: 99% identity (159/160 amino acids identical)
Human: 98% identity (157/160 amino acids identical)
<50% identity with Kv4.3
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Human; Rat; Mouse
Clonality
Monoclonal
Isotype
IgG1
Clone Number
L28/4
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with Kv4.3 (based on KO validation results)
Research Areas
K+ channels
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
KCND2
Official Name
KCND2
Full Name
Kv4.2 K+ channel
Alternative Names
KCND2; KV4.2; RK5; potassium voltage-gated channel subfamily D member 2
Uniprot ID
Q63881
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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