NeuroMab™ Anti-NALCN BBB Shuttle Antibody, Clone N185/7

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-NALCN BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1659-1738 (cytoplasmic C-terminus) of rat NALCN (also known as Sodium leak channel non-selective protein, Four domain-type voltage-gated ion channel alpha-1 subunit, Voltage-gated channel-like protein 1, Vgcnl1, Nca and Cankon, accession number Q6Q760)
Mouse: 98% identity (79/80 amino acids identical)
Human: 95% identity (76/80 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N185/7

Applications

WB; IHC; ICC

Research Areas

Ion channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

NALCN

Official Name

NALCN

Full Name

NALCN

Alternative Names

Sodium leak channel non-selective protein; Four domain-type voltage-gated ion channel alpha-1 subunit; Voltage-gated channel-like protein 1; Vgcnl1; Nca and Cankon