NeuroMab™ Rat Anti-Dectin-2 Monoclonal Antibody (CBP2586)

Product Overview

Description

Rat anti-Mouse Dectin-2 antibody, recognizes the C-type lectin-2 (Dectin-2) associated with mouse DC. Type II transmembrane protein is a member of the C-type lectin superfamily. In mice, dectin-2 is mainly expressed on tissue macrophages and some dendritic cells. Clone D2.11E4 does not stain brain microglia or meningeal macrophages. It is reported that Dectin-2 is expressed importantly in macrophages in the marginal area of the red plasma and spleen, Kupffer cells in the liver, and alveolar macrophages in the lung. Peripheral blood monocytes express low levels of dectin-2, but transient up-regulation of expression has been demonstrated on monocytes at sites of inflammation.

Immunogen

Dectin-2 (extracellular domain) Fc fusion protein.

Species Reactivity

Mouse

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG2a

Clone Number

CBP2586

Applications

FC; IHC-Fr; IP

Application Notes

FC: 1/10-1/100

Relevant Diseases

Alzheimer's Disease; Neurodegenerative Disease

Research Areas

Neuroregeneration

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1882

Product Properties

Form

Liquid

Formulation

PBS

Preservatives

BSA free

Concentration

1 mg/ml

Purification

Protein G

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C only. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Clec4n

Official Name

CLEC6A

Full Name

C-type lectin domain containing 6A

Alternative Names

CLEC4N; CLECSF10; dectin-2

Gene ID

93978(Human)

Uniprot ID

Q6EIG7(Human)

References

1. Suram, S. et al. (2010) Pathways regulating cytosolic phospholipase A2 activation and eicosanoid production in macrophages by Candida albicans.
2. Barrett, N.A. et al. (2011) Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes.
3. Robinson, M. et al. (2009) Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection.
4. McDonald, J.U. et al. (2012) Differential dependencies of monocytes and neutrophils on dectin-1, dectin-2 and complement for the recognition of fungal particles in inflammation.

Publications