NeuroMab™ Anti-GluN2C/NR2C BBB Shuttle Antibody, Clone N422/18

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GluN2C BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 836-1233 (cytoplasmic C-terminus) of rat GluN2C (also known as Glutamate receptor ionotropic NMDA 2C, Glutamate [NMDA] receptor subunit epsilon-3, Nmethyl D-aspartate receptor subtype 2C, NMDAR2C, NR2C and Grin2c, accession number Q00961)
Mouse: 93% identity (372/400 amino acids identical)
Human: 72% identity (293/405 amino acids identical)
<30% identity with GluN2D/NR2D and other GluN/NMDA receptors

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N422/18

Applications

WB; IHC; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

GluN2C

Official Name

GRIN2C

Full Name

GluN2C/NR2C glutamate receptor

Alternative Names

GRIN2C; GluN2C; NMDAR2C; NR2C; glutamate ionotropic receptor NMDA type subunit 2C

Uniprot ID

Q00961

Product Pictures

Fig. 1 Immunoblot versus crude membrane fractions from GluN2C/NR2C knockout (KO) and wild-type (WT) mouse cerebella probed with N422/18 (top) and tubulin (bottom).

Fig. 2 Immunofluorescence staining of sections from adult GluN2C/NR2C wild-type (WT) and knockout (KO) mouse cerebellum with N422/18 (GluN2C/NR2C, red) and L106/83 (Gephyrin, green) TC supe.