NeuroMab™ Anti-GluN2C/NR2C BBB Shuttle Antibody, Clone N422/18
[CAT#: NRZP-0423-ZP152]
- Species Reactivity:
- Rat; Mouse; Human
- Applications:
- WB; IHC; ICC
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GluN2C BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 836-1233 (cytoplasmic C-terminus) of rat GluN2C (also known as Glutamate receptor ionotropic NMDA 2C, Glutamate [NMDA] receptor subunit epsilon-3, Nmethyl D-aspartate receptor subtype 2C, NMDAR2C, NR2C and Grin2c, accession number Q00961)
Mouse: 93% identity (372/400 amino acids identical)
Human: 72% identity (293/405 amino acids identical)
<30% identity with GluN2D/NR2D and other GluN/NMDA receptors
Mouse: 93% identity (372/400 amino acids identical)
Human: 72% identity (293/405 amino acids identical)
<30% identity with GluN2D/NR2D and other GluN/NMDA receptors
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Rat; Mouse; Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
N422/18
Applications
WB; IHC; ICC
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
GluN2C
Official Name
GRIN2C
Full Name
GluN2C/NR2C glutamate receptor
Alternative Names
GRIN2C; GluN2C; NMDAR2C; NR2C; glutamate ionotropic receptor NMDA type subunit 2C
Uniprot ID
Q00961
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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