NeuroMab™ Anti-HCN3 cyclic nucleotide-gated channel BBB Shuttle Antibody, Clone N141/28

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-HCN3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 660-779 (cytoplasmic C-terminus) of mouse HCN3 (also known as potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3, hyperpolarization-activated cation channel 3 and HAC-3, accession number O88705)
Rat: 98% identity (118/120 amino acids identical)
Human: 86% identity (105/121 amino acids identical)
<50% identity with HCN1, HCN2 and HCN4

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N141/28

Applications

WB; IHC; ICC

Application Notes

No cross-reactivity against other HCN's

Research Areas

Ion channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

HCN3

Official Name

HCN3

Full Name

HCN3

Alternative Names

Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 3; Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 3; KIAA1535;