NeuroMab™ Anti-Notch3 BBB Shuttle Antibody(NRZP-1022-ZP3228)
[CAT#: NRZP-1022-ZP3228]
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA; WB; IHC; FC; Inhib; Agonist; In Vitro; In Vivo
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Immunogen
Notch3 Extracellular Domain-FC Fusion Protein
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Applications
ELISA; WB; IHC; FC; Inhib; Agonist; In Vitro; In Vivo
Relevant Diseases
Alzheimer's Disease; Epilepsy; Pain
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
Notch3
Official Name
NOTCH3
Full Name
Notch 3
Alternative Names
Notch 3; Neurogenic Locus Notch Homolog Protein 3; Notch (Drosophila) Homolog 3; Notch Homolog 3 (Drosophila); Notch Homolog 3; CADASIL1;
Product Pictures
Inhib
Figure 1 depicts a luciferase reporter assay showing inhibition of the Notch3 ligand Jagged 1 by anti-Notch3 MAbs.
Inhib
Figure 2 depicts a luciferase reporter assay showing inhibition of the Notch3 ligand Jagged 2 by an anti-Notch3 MAb.
Inhib
Figure 3 depicts a luciferase reporter assay showing the inhibitory effect of anti-Notch3 MAbs on the Notch3 ligand DLL4.
Inhib
Figure 4 depicts a luciferase reporter assay showing the inhibitory effect of anti-Notch3 MAbs on native Notch3 in ovarian cancer cells.
FuncS
Figure 5 depicts an apoptosis assay showing that Jagged1-induced cell survival effects are inhibited by anti-Notch3 MAbs.
FuncS
Figure 6 depicts the inhibitory effect of anti-Notch3 MAbs on cell migration.
ELISA
Figure 7 depicts an ELISA using 256A-4 as the detection antibody.
Publications
Publications (0)
Neural Antibodies
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
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