Mouse Anti-SERPINA3 Monoclonal Antibody (CBP6828)

Description

Neuroinflammatory process is a key pathogenic factor Brain and spinal cord injury in the back. This applies not only to Acute brain injury and hypoxic-ischemic brain injury Stroke, but also used for chronic infections and neurodegenerative diseases Diseases such as Alzheimer's disease (AD), amyotrophic lateral cord Sclerosis (ALS), Lewy Body Dementia (LBD) and Multiple Sclerosis (Multiple sclerosis). In addition, local inflammation around the tumor also plays a role In the clinical progression and malignancy of glioblastoma, The most aggressive primary brain tumor. α1-Antichymotrypsin (symbol α1AC, A1AC or a1ACT) is an alpha globulin glycoprotein and a member of the superfamily of serine protease inhibitors. In humans, it is encoded by the SERPINA3 gene.

α1-Antichymotrypsin can inhibit the activity of certain enzymes called proteases by cutting them into different shapes or conformations, such as cathepsin G found in neutrophils and mast cells Chymase. This activity can protect certain tissues, such as the lower respiratory tract, from damage by proteolytic enzymes.

This protein is produced in the liver and is an acute phase protein induced during inflammation.

Epitope

Binds to an located within the peptide sequence QDKMEEVEAMLLPET

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP6828

Applications

IHC

Application Notes

IHC: 1:2500-1:5000

Relevant Diseases

Neuroinflammation; Neurodegenerative Disease; Alzheimer's Disease; Amyotrophic Lateral Sclerosis; Lewy body dementia

Research Areas

Neuroinflammation; Neurodegeneration

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

1 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

AACT

Official Name

SERPINA3

Full Name

Alpha 1-antichymotrypsin

Alternative Names

SERPINA3; AACT; ACT; GIG24; GIG25; serpin family A member 3

Gene ID

12 (Human); 20714 (Mouse)

Uniprot ID

P01011 (Human); P07759 (Mouse)