NeuroMab™ Anti-HCN1 cyclic nucleotide-gated channel BBB Shuttle Antibody, Clone N70/28

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-HCN1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 778-910 (cytoplasmic C-terminus) of rat HCN1 (also known as potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, accession number Q9JKB0)
Mouse: 96% identity (128/133 amino acids identical)
Human: 90% identity (121/133 amino acids identical)
<50% identity with HCN2, HCN3 and HCN4

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N70/28

Applications

WB; IHC; IP; ICC

Application Notes

No cross-reactivity against HCN2

Research Areas

Ion channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

HCN1

Official Name

HCN1

Full Name

HCN1

Alternative Names

Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 1; Brain Cyclic Nucleotide-Gated Channel 1; BCNG-1; BCNG1; Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 1; Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1; EIEE24; HAC-2;

Uniprot ID

Q9JKB0

Product Pictures

Fig. 1 Adult rat and mouse brain membrane (RBM and MBM, respectively) and transfected cell immunoblot: extracts of RBM, HCN1-KO and -WT MBM and COS-1 cells transfected with GFP-HCN1, GFP-HCN2 or Kv2.1 plasmids and probed with N70/28 (left panel) or K89/34 TC supe (right panel).