Neuroinflammation Antibodies

Cytokines mediate communication between cells and are involved in the activities of complex cell behaviors. Neuroinflammation is a prevalent sign of neurological disorders such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Huntington's disease (HD). The neuroinflammatory response plays a significant role in the development of brain injury and is frequently accompanied by the release of proinflammatory cytokines and chemokines.

Central Nervous System (CNS) and Immune System

Astrocytes and microglia have key immunomodulatory activities in the CNS. In particular, microglia play an important role in sensing environmental changes, responding to noxious stimuli, and phagocytosing debris and apoptotic neurons. By exposing T cells to antigens, microglia also facilitate communication between the immune system and the central nervous system. Furthermore, microglia release soluble molecules that can either promote or inhibit neuroinflammation, just like astrocytes and neurons do.

Fig.1 Representative images of primary rat spinal cord cells, GFAP (astrocyte marker) and Iba1 (microglia marker). Images were acquired using Zeiss LSM 980.

Inflammatory Cytokines

Neuroinflammation, which is common in inflammatory demyelinating diseases (e.g., multiple sclerosis) and infections (bacterial and viral encephalitis), is characterized by leukocyte invasion of the CNS and disruption of the integrity of the blood-brain barrier (BBB). Lymphocytes and myeloid cells are major mediators of tissue damage, delivering cytokines to tissues that promote the inflammatory cascade. Many proinflammatory cytokines are key players in neuroinflammation mediated by infiltrating leukocytes.

Creative Biolabs has a long and successful track record as a focused neuroinflammation antibody supplier. Please contact us to learn more about our antibody products for neurological diseases.