NeuroMab™ Mouse Anti-CD14 Monoclonal Antibody (CBP1941)

Product Overview

Description

Mouse anti-human CD14 antibody recognizes human CD14, also known as myeloid cell-specific leucine-rich glycoprotein. CD14 is a 375 amino acid, approximately 55 kDa GPI-anchored cell membrane protein. It is mainly found on monocytes and macrophages. It is weakly expressed on granulocytes and is very early differentiated stem cells and bone marrow cells. Does not exist in. In immunohistology, CD14 is present on Langerhans cells, follicular dendritic cells, histiocytes and high endothelial venules. In the ELISA clone, MEM-18 recognizes the soluble form of CD14, and has been successfully used as a capture reagent in the development of sensitive ELISA, and used in combination with the biotinylated Mouse anti CD14 antibody, clone UCHM1 as a detection reagent.

Immunogen

Crude protein prepared by ammonium sulfate precipitation in the urine of patients with proteinuria.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP1941

Applications

Application Notes

FC (1/10)

Relevant Diseases

Lou Gehring's Disease

Research Areas

Neuroregeneration

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1576

Product Properties

Form

Liquid

Formulation

PBS; 0.09% Sodium Azide
1% Bovine Serum Albumin

Preservatives

Yes

Concentration

0.1 mg/ml

Purification

Purified IgG prepared by affinity chromatography on Protein A.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD14

Official Name

CD14

Full Name

CD14 Molecule

Alternative Names

CD14 Molecule; CD14 Antigen; Myeloid Cell-Specific Leucine-Rich Glycoprotein

Gene ID

929(Human); 12475(Mouse); 60350(Rat)

Uniprot ID

P08571(Human); P10810(Mouse); Q63691(Rat)

References

1. Paul, G. et al. (2012) The adult human brain harbors multipotent perivascular mesenchymal stem cells.
2. Angel, C.E. et al. (2006) Cutting edge: CD1a+ antigen-presenting cells in human dermis respond rapidly to CCR7 ligands.
3. Shao, D.D. et al. (2008) Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation.
4. Silk, K.M. et al. (2012) Rapamycin conditioning of dendritic cells differentiated from human ES cells promotes a tolerogenic phenotype.

Publications