NeuroMab™ Rat Anti-HSF1 Monoclonal Antibody (CBP2510)
[CAT#: NAB2010651LS]
Anti HSF1 Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Human; Mouse
- Applications:
- IHC-P; WB; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
HSF1 is a DNA-binding protein that exists as an inactive monomer in a complex with Hsp40/Hsp70 and Hsp90. Upon stress, HSF1 is released from the chaperone complex and trimerizes. HSF1 is then transported into the nucleus where it is hyperphosphorylated and binds to DNA containing heat shock elements (HSE) and activates transcription of proteins such as HSP70. HSP70 is known to inhibit the tau and alpha synuclein aggregation seen in Alzheimer's Disease and Parkinson's Disease.
Immunogen
This monoclonal antibody was raised against mouse recombinant HSF-1 protein and was mapped to amino acids 425-439.
Species Reactivity
Human; Mouse
Clonality
Monoclonal
Host Species
Rat
Isotype
IgG2a, κ
Clone Number
CBP2510
Applications
IHC-P; WB; ICC
Application Notes
The optimal working dilutions shoµld be determined by the end user.
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation
Conjugation
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1837
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide
Concentration
0.5 mg/ml
Purification
Affinity chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Endotoxin Level
Low Endotoxin
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
The antibody solution should be stored undiluted between 2°C and 8°C.
Handling Advice
Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
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