NeuroMab™ Anti-FGFR2 BBB Shuttle Antibody,Clone NR3189P
- Host Species:
- Human
- Species Reactivity:
- Human
- Applications:
- In Vitro; In Vivo
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Figure 1: Induction level of phosphorylated FGFR2 (P-FGFR2) in MFM223 after a short (15 min) incubation with 10 μg/ml anti-FGFR2 antibody. Y is the % of untreated and control cells
Figure 2: After long-term incubation (24 hours) with 10 μg/ml anti-FGFR2 antibody, the induction of FGF7 (25ng/ml, 15min)-mediated P-FGFR2 levels in MFM223 cells is desensitized. Y is compared with control cells Unprocessed percentage
Figure 3: FGFR2 surface expression was downregulated in FGFR2 overexpressing (MFM223, SNU16) or FGFR2 mutant (AN3-CA, MFE-296) cell lines after 4.5 hours of incubation with 10 μg/ml anti-FGFR2 antibody (investigated by FACS analysis).
Figure 4: Total FGFR2 levels decreased after prolonged incubation (96 hours) with anti-FGFR2 antibodies in SNU16 cells.
Figure 5: Microscopic evaluation of the time course of the specific internalization of M048-D01-hIgG1 and M047-D08-hIgG1 after binding to cells expressing endogenous FGFR2.
Figure 6: Internalization of M048-D01-hIgG1 (A, B) and M047-D08-hIgG1 (C, D) in SUM52PE cells
Figure 7 Total FGFR2 [total FGFR2] and FGFR2 phosphorylation after M048-D01-hIgG1 and M047-D08-hIgG1 treatment
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