NeuroMab™ Anti-HMGB1 BBB Shuttle Antibody(NRZP-1022-ZP4015)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a/κ

Applications

ELISA; WB; Antagonist

Relevant Diseases

Neuroinflammation

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

HMGB1

Official Name

HMGB1

Full Name

High-mobility group box 1

Alternative Names

HMGB1; High-mobility group box 1

Product Pictures

ELISA

Figure 1 shows the ELISA detection of plasma HMGB1 in blood samples taken from the heart of the LPS-induced sepsis model at 4h, 12h, and 24h, respectively, which were established using monoclonal antibodies against 2D4E3A2 hypercytosis. *p<0.01.

Figure 2 The expression level of HMGB1 in scavenger cells was detected by Western blot using 2D4E3A2 monoclonal antibody.

FuncS

Figure 3 The increase of 2D4E3A2 cells can effectively reduce the myocardial injury caused by myocarditis. C represents the control group, E represents the experimental group, and EB represents the 2D4E3A2 antibody intervention group.

Publications