NeuroMab™ Anti-HMG1 BBB Shuttle Antibody(NRZP-1022-ZP3161)
[CAT#: NRZP-1022-ZP3161]
- Host Species:
- Human
- Species Reactivity:
- Human
- Applications:
- ELISA; Inhib; In Vitro; In Vivo
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Human
Applications
ELISA; Inhib; In Vitro; In Vivo
Relevant Diseases
Neuroinflammation
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
HMGB1
Official Name
HMGB1
Full Name
High-mobility group box 1
Alternative Names
HMGB1; High-mobility group box 1
Product Pictures
ELISA
Figure 1 Binding kinetics and specificity of human anti-HMG1 antibodies.
HMG1 capture ELISA binding curves of several human anti-HMG1 antibodies demonstrate that these antibodies have different affinities for recombinant HMG1 produced in E. coli.
Inhib
Figure 2 A number of human anti-HMG1 antibodies inhibited HMG1-stimulated cytokine release from human PBMCs.
Inhib
Figure 3 Several human anti-HMG1 antibodies inhibit HMG1-stimulated cytokine gene expression in mouse macrophages (mMO).
Block
Figure 4. A subset of human anti-HMG1 antibodies block the binding of recombinant HMG1 to RAGE.
IHC
Figure 5 HMG1 staining pattern in human brain tissue from multiple sclerosis (MS) specimens.
Specific HMGB1 staining of the cytoplasm of the microglia and the interstitia of an MS Plaque with Activated Microglia using 1 μg/ml G16.
Publications
Publications (0)
Neural Antibodies
Kits
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
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