NeuroMab™ Anti-IFN Gamma BBB Shuttle Antibody(NRZP-1022-ZP2813)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Human

Applications

Block; Neut; Inhib; FC; In Vivo; In Vitro

Relevant Diseases

Neuroinflammation

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

IFNGamma

Official Name

IFNG

Full Name

IFN gamma

Alternative Names

GD2

Product Pictures

FuncS

Figure 1 is a graph depicting the affinity of NI-0501 huIFNγ antibody for human IFNγ.

FuncS

Figure 2 is a graph comparing antibody activity produced by clones A6 and NI-0501 (also referred to herein as "A6 backmutated to germline" or "backmutated A6") clones.