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Creative Biolabs

NeuroMab™ Anti-Tenascin C Antibody(NRP-0422-P755)

[CAT#: NRP-0422-P755]

A functional antibody raised against Human, Cynomolgus Monkey, Mouse TNC.

Host Species:
Human
Species Reactivity:
Human; Cynomolgus Monkey; Mouse
Applications:
ELISA; IHC; FC; ADCC; Cyt; In Vitro; In Vivo

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Product Overview

Description

The antibody against the A2 domain of tenascin-C and has a range of therapeutic uses, such as therapeutic uses in the diagnosis and treatment of cancer.

Species Reactivity

Human; Cynomolgus Monkey; Mouse

Clonality

Monoclonal

Host Species

Human

Applications

ELISA; IHC; FC; ADCC; Cyt; In Vitro; In Vivo

Relevant Diseases

Neuroinflammation; Tumor
Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only
Target

Target

TenascinC

Official Name

TNC

Full Name

Tenascin C

Alternative Names

TNC; 150-225; DFNA56; GMEM; GP; HXB; JI; TN; TN-C; Tenascin C

Gene ID

3371(Human)

Uniprot ID

P24821(Human)
Product Pictures
FuncS

Figure 1 shows the binding of anti-TNC A2 antibody 2B10 as wild type (wt) and glycoengineered (ge) versions to TNC A2 on U87MG cells.

Staining with an isotype control antibody is shown at 100X magnification (right panel). Top: normal tissue, bottom: tumor tissue from the brain.

FCM

Figure 2 shows the binding of 2B10-derived human IgG to TNC A2 expressed on U87MG glioblastoma tumor cells as determined by flow cytometry.

Staining with an isotype control antibody is shown at 100X magnification (right panel). Top: normal tissue, bottom: tumor tissue from the brain.

IHC

Figure 3 shows immunohistochemical images of human tissue stained with 2B10-mouse IgG at 100× (left panel) and 400× (middle panel) magnifications.

Staining with an isotype control antibody is shown at 100X magnification (right panel). Top: normal tissue, bottom: tumor tissue from the brain.

SPR

Figure 4 shows the SPR-based kinetic analysis of the binding of 2B10 anti-TNC A2 Fab fragment to human TNC A2.

Staining with an isotype control antibody is shown at 100X magnification (right panel). Top: normal tissue, bottom: tumor tissue from the brain.

SPR

Figure 5 shows the SPR-based kinetic analysis of 2B10 anti-TNC A2 Fab fragments binding cynomolgus monkey TNC A3.

Staining with an isotype control antibody is shown at 100X magnification (right panel). Top: normal tissue, bottom: tumor tissue from the brain.

SPR

Figure 6 shows the SPR-based kinetic analysis of the binding of the 2B10 anti-TNC A2 Fab fragment to murine TNC A3.

Staining with an isotype control antibody is shown at 100X magnification (right panel). Top: normal tissue, bottom: tumor tissue from the brain.

Publications

Publications (0)

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