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NeuroMab™ Anti-TREM2 Antibody,Clone NR2545P
A functional antibody raised against Human TREM2.
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FC; IHC; Cyt; ADCP; In Vitro; In Vivo
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryDescription
Species Reactivity
Clonality
Host Species
Clone Number
Applications
Relevant Diseases
Formulation
Preservatives
Concentration
Purification
Purity
Endotoxin Level
Low Endotoxin < 1 EU/mg
Shipping
Storage
Research Use Only
Figure 1 demonstrates that anti-NSM antibodies reduced tumor growth relative to controls to the same extent as anti-PD-1 therapy.
MC38 colon carcinomas were injected into B6 6-week-old male mice. Mice randomly assigned to treatment groups were treated with the indicated antibodies by IP injection on days 5, 7, 11, and 15. Shown is the 75% rank (removing top outliers and plotting bottom 3 of 4 mice). Administration: PD-1 and Fc control 200ug per day, 40ug, 20ug, 20ug and 40ug anti-Pil.2 (aTREM2) antibody were injected on the 5th, 7th, 11th and 15th day respectively. Via calipers and display tumor volume.
Figure 2 shows the binding characteristics of anti-TREM2 antibodies (Pil.2 Clone 2, Pil.2, Clone 5, and Pil.2 Clone 7). absolute absorption
Figure 3 shows transfectants stained with anti-TREM2 antibody (Pil.2 clone 2). EL4-TREM2+ cells are marked with an unshaded black histogram, while parental EL4 cells are marked with a shaded gray histogram.
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