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Creative Biolabs
Product

NeuroMab™ Anti-TREM2 Antibody, Clone Clone 2

[CAT#: NRP-0422-P790]

A functional antibody raised against Human TREM2.

Host Species:
Mouse
Species Reactivity:
Human
Applications:
FC; IHC; Cyt; ADCP; In Vitro; In Vivo

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Product Overview

Description

The anti-TREM2 antibody can be used for enhancing an immune response and/or for the treatment of an immune-related condition in an individual.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Clone Number

Clone 2

Applications

FC; IHC; Cyt; ADCP; In Vitro; In Vivo
Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only
Target

Target

TREM2

Official Name

TREM2

Full Name

Triggering receptor expressed on myeloid cells 2

Alternative Names

TREM2; Triggering receptor expressed on myeloid cells 2

Gene ID

54209(Human)

Uniprot ID

Q9NZC2(Human)
Product Pictures
FuncS

Figure 1 demonstrates that anti-NSM antibodies reduced tumor growth relative to controls to the same extent as anti-PD-1 therapy.

MC38 colon carcinomas were injected into B6 6-week-old male mice. Mice randomly assigned to treatment groups were treated with the indicated antibodies by IP injection on days 5, 7, 11, and 15. Shown is the 75% rank (removing top outliers and plotting bottom 3 of 4 mice). Administration: PD-1 and Fc control 200ug per day, 40ug, 20ug, 20ug and 40ug anti-Pil.2 (aTREM2) antibody were injected on the 5th, 7th, 11th and 15th day respectively. Via calipers and display tumor volume.

ELISA

Figure 2 shows the binding characteristics of anti-TREM2 antibodies (Pil.2 Clone 2, Pil.2, Clone 5, and Pil.2 Clone 7). absolute absorption

FCM

Figure 3 shows transfectants stained with anti-TREM2 antibody (Pil.2 clone 2). EL4-TREM2+ cells are marked with an unshaded black histogram, while parental EL4 cells are marked with a shaded gray histogram.

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