NeuroMab™ Mouse Anti-Dectin-1 Monoclonal Antibody (CBP2583)

Product Overview

Description

Mouse anti-human Dectin-1 antibody, recognizes human Dectin-1, also known as β-glucan receptor (βGR), a member of the C-type lectin domain family. It is a major pathogen pattern recognition receptor, which can be combined with β-glucan, glucose polymer that forms the cell wall component, or outer polymer of yeast, fungi and certain bacteria. Beta-glucan has also been used in experiments and treatments as an immunomodulator to enhance resistance to bacterial, yeast, viral and protozoan infections and tumor formation. Dectin-1 also acts as a costimulatory molecule on T cells to induce their proliferation, and is required for TLR2-mediated inflammation. It is highly expressed on peripheral blood leukocytes and dendritic cells. Human Dectin-1 has two main isomers (βGR-A and βGR-B). βGR-A and βGR-B are different due to the presence and absence of the stem region, respectively. Mouse anti-human Dectin-1 antibody, recognizes βGR-A.

Immunogen

NIH3T3 cells express full-length β-glucan receptors.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b

Clone Number

CBP2583

Applications

Relevant Diseases

Alzheimer's Disease; Neurodegenerative Disease

Research Areas

Neuroregeneration

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1879

Product Properties

Form

Liquid

Formulation

PBS, 0.09% Sodium Azide

Preservatives

YES

Concentration

0.05 mg/ml

Purification

Protein G

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CLEC7A

Official Name

CLEC7A

Full Name

C-Type Lectin Domain Containing 7A

Alternative Names

C-Type Lectin Domain Containing 7A; C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 12; C-Type Lectin Domain Family 7 Member A; C-Type Lectin Superfamily Member 12; DC-Associated C-Type Lectin 1; Beta-Glucan Receptor; Dectin-1; CLECSF12; DECTIN1;

Gene ID

64581(Human); 56644(Mouse); 502902(Rat)

Uniprot ID

Q9BXN2(Human); Q6QLQ4(Mouse)

References

1. Willment, J.A. et al. (2005) The human beta-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells.
2. Hoeksema, M.A. et al. (2014) Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions.

Publications