NeuroMab™ Rat Anti-Dectin-1 Monoclonal Antibody (CBP2585)

Product Overview

Description

Rat anti-Mouse Dectin-1 antibody, recognizes murine β-glucan receptor, also known as Dectin-1. Dectin-1 is mainly expressed by cells of the monocyte/macrophage and neutrophil lineage, But in dendritic cells and T cell subsets. As the main leukocyte receptor of β-glucan, this molecule may play a key role in the immunomodulation of β-glucan and the host's response to fungal pathogens. Dectin-1 may stimulate the production of reactive oxygen species in macrophages through a protein tyrosine kinase called Syk. The rat anti-Mouse Dectin-1 antibody, clone 2A11, inhibits the binding of zymosan to macrophages via the β-glucan receptor.

Immunogen

Dectin-1 transfected NIH3T3 cells and recombinant soluble Dectin-1.

Species Reactivity

Mouse

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG2b

Clone Number

CBP2585

Applications

Application Notes

FC: 1/10

Relevant Diseases

Alzheimer's Disease; Neurodegenerative Disease

Research Areas

Neuroregeneration

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1881

Product Properties

Form

Liquid

Formulation

PBS, 0.09% Sodium Azide, 1% BSA

Preservatives

YES

Concentration

0.05 mg/ml

Purification

Protein G

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CLEC7A

Official Name

CLEC7A

Full Name

C-Type Lectin Domain Containing 7A

Alternative Names

C-Type Lectin Domain Containing 7A; C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 12; C-Type Lectin Domain Family 7 Member A; C-Type Lectin Superfamily Member 12; DC-Associated C-Type Lectin 1; Beta-Glucan Receptor; Dectin-1; CLECSF12; DECTIN1;

Gene ID

64581(Human); 56644(Mouse); 502902(Rat)

Uniprot ID

Q9BXN2(Human); Q6QLQ4(Mouse)

References

1. Taylor, P.R. et al. (2002) The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages.
2. Reid, D.M. et al. (2004) Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions.
3. Underhill, D.M. et al. (2005) Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production.
4. Lefevre,L. et al. (2010) PPARc Ligands Switched High Fat Diet-Induced Macrophage M2b Polarization toward M2a Thereby Improving Intestinal Candida Elimination

Publications