NeuroMab™ Mouse Anti-Dectin-1 Monoclonal Antibody (CBP2584)

Product Overview

Description

Mouse anti-human Dectin-1 antibody, recognizes human Dectin-1, also known as β-glucan receptor (βGR), a member of the C-type lectin domain family. It is a major pathogen pattern recognition receptor, which can be combined with β-glucan, the glucose polymer that forms the cell wall component, or the outer polymer of yeast, fungi and certain bacteria. β-glucan has also been used in experiments and treatments as an immunomodulator to enhance resistance to bacterial, yeast, viral and protozoan infections and tumor formation. Dectin-1 also acts as a costimulatory molecule on T cells to induce their proliferation, and is required for TLR2-mediated inflammation. It is highly expressed on peripheral blood leukocytes and dendritic cells.

Immunogen

NIH3T3 cells express full-length β-glucan receptors.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2584

Applications

Relevant Diseases

Alzheimer's Disease; Neurodegenerative Disease

Research Areas

Neuroregeneration

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1880

Product Properties

Form

Liquid

Formulation

PBS, 0.09% Sodium Azide, 1% BSA

Preservatives

YES

Concentration

0.05 mg/ml

Purification

Protein A

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CLEC7A

Official Name

CLEC7A

Full Name

C-Type Lectin Domain Containing 7A

Alternative Names

C-Type Lectin Domain Containing 7A; C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 12; C-Type Lectin Domain Family 7 Member A; C-Type Lectin Superfamily Member 12; DC-Associated C-Type Lectin 1; Beta-Glucan Receptor; Dectin-1; CLECSF12; DECTIN1;

Gene ID

64581(Human); 56644(Mouse); 502902(Rat)

Uniprot ID

Q9BXN2(Human); Q6QLQ4(Mouse)

References

1. Willment, J.A. et al. (2005) The human beta-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells.
2. Harnack, U. et al. (2011) Yeast-derived beta-(1-3),(1-6)-D-glucan induces up-regulation of CD86 on dectin-1-positive human B-lymphoma cell lines.
3. Loures, F.V. et al. (2015) Recognition of Aspergillus fumigatus hyphae by human plasmacytoid dendritic cells is mediated by dectin-2 and results in formation of extracellular traps.
4. Kyrmizi, I. et al. (2013) Corticosteroids block autophagy protein recruitment in Aspergillus fumigatus phagosomes via targeting dectin-1/Syk kinase signaling.

Publications