NeuroMab™ Anti-AGPS neo-epitope BBB Shuttle Antibody, Clone N444/63

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-AGPS BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 59-67 (KARRAASAA, site of proteolytic processing for peroxisome import) of human AGPS (also known as Alkylglycerone-phosphate synthase, Peroxisomal alkyldihydroxyacetonephosphate synthase, Alkyl-DHAP synthase, Aging-associated gene 5 protein, Ads and AAG5, accession number O00116)
Mouse: 100% identity (9/9 amino acids identical)
Rat: 100% identity (9/9 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N444/63

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with unprocessed AGPS

Research Areas

Rare Disease

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

AGPS

Official Name

AGPS

Full Name

AGPS neo-epitope

Alternative Names

Aging-Associated Gene 5 Protein ; Alkyl-DHAP Synthase ; EC 2.5.1.26 ; ALDHPSY ; ADAP-S ; ADHAPS ; ADAS ; ADPS ; Alkylglycerone-Phosphate Synthase ; Aging-Associated Protein 5; RCDP3; AGPS

Uniprot ID

O00116

Product Pictures

Fig. 1 Adult rat brain membrane (RBM) and human cell immunoblot: lysates of RBM and fibroblasts from unaffected (control/normal) and disease-affected (patient/Pex5-mutant) humans probed with N444/63 TC supe (left) and rabbit polyclonal (right).