NeuroMab™ Anti-Dicer BBB Shuttle Antibody, Clone N167/7

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Dicer BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1638-1899 of mouse Endoribonuclease Dicer (also known as Dicer1, DCR, DCR-1, Double-strand-specific ribonuclease, Helicase with RNase motif, HERNA, Helicase MOI and KIAA0928, accession number Q8R418)
Human: 99% identity (257/262 amino acids identical)
Rat: 99% identity (257/262 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N167/7

Applications

WB; IHC; ICC

Research Areas

Epigenetics

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Dicer

Official Name

DICER1

Full Name

Dicer

Alternative Names

DICER1; DCR1; Dicer; Dicer1e; HERNA; MNG1; RMSE2; K12H4.8-LIKE; dicer 1; ribonuclease III; GLOW

Uniprot ID

Q8R418

Product Pictures

Fig. 1 Immunoblot versus adult rat brain membranes (RBM) and extracts of embryonic stem (ES) cells from wild-type (WT) and Dicer knockout (KO) mice probed with N167/7 (left) and N52A/42 (right, loading control) TC supe.

Publications