NeuroMab™ Anti-DNAIC1 BBB Shuttle Antibody, Clone UNC 65.56.18.11

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-DNAI1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 22-41 (RGTRKRDEDSGTEVGEGTDE) of human DNAIC1 (also known as Axonemal dynein intermediate chain 1 and Dnai1, accession number Q9UI46)
Mouse: 85% identity (17/20 amino acids identical)
Rat: 75% identity (15/20 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

UNC 65.56.18.11

Applications

WB; IHC; ICC

Research Areas

Rare Disease

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

DNAI1

Official Name

DNAI1

Full Name

DNAIC1

Alternative Names

DNAI1; CILD1; DIC1; ICS1; PCD; dynein axonemal intermediate chain 1

Uniprot ID

Q9UI46

Product Pictures

Fig. 1 Immunoblot against isolated cilia and extracts of COS cells transiently transfected with GFP-tagged DNAIC1 or untagged Kv2.1 plasmid probed with UNC 65.56.18.11 (left) or N52A/42 (right) TC supe.

Publications