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Creative Biolabs

NeuroMab™ Anti-EPHA2 BBB Shuttle Antibody(NRZP-1022-ZP3864)

[CAT#: NRZP-1022-ZP3864]

Host Species:
Mouse
Species Reactivity:
Human
Applications:
WB

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

WB

Relevant Diseases

Glioblastoma Multiforme
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

EPHA2

Official Name

EPHA2

Full Name

EPH receptor A2 (ephrin type-A receptor 2)

Alternative Names

EPHA2; Epha2; AW545284; Eck; Myk2; Sek-2; Sek2; ARCC2; CTPA; CTPP1; CTRCT6; EPH receptor A2; ECK
Product Pictures
WB

Figure 1A is a graph showing the results of Western blotting showing whether an anti-EPHA2 antibody induces phosphorylation activity of EPHA2 tyrosine residues.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1A is a graph showing the results in the absence of a cross-linked antibody. The upper bar shows the results for the 4G10 antibody, and the lower bar shows the results for the anti-EPHA2 antibody (D7).

WB

Figure 1B is a graph showing the Western blotting results of the presence or absence of the phosphorylation activity of EPHA2 tyrosine residues induced by anti-EPHA2 antibodies.

Fig. 1B is a graph showing the results in the presence of cross-linked antibodies, the upper part is the result of 4G10 antibody, and the lower part is the result of anti-EPHA2 antibody (D7).

WB

Figure 2A is a graph showing the results of Western blot showing whether an anti-EPHA2 antibody has the activity of inducing a decrease in EPHA2 protein level.

Figure 2A is a graph representing the results obtained in the absence of cross-linked antibodies, wherein the upper column represents the results for the anti-EPHA2 antibody (D7) and the lower column represents the results for the anti-β-actin antibody.

WB

Figure 2B is a graph showing the results of Western blot showing whether the anti-EPHA2 antibody has the activity of inducing the decrease of EPHA2 protein level.

Figure 2B is a graph showing the results in the presence of a cross-linked antibody, the upper column represents the results for the anti-EPHA2 antibody (D7), and the lower column represents the results for the anti-β-actin antibody;

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