NeuroMab™ Anti-GABA-A-R-Beta1 BBB Shuttle Antibody, Clone N96/55

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GABRB1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 327-450 (cytoplasmic loop) of mouse GABA-A-R-Beta1 (also known as Gamma-aminobutyric acid receptor subunit beta-1, accession number P50571)
Rat: 99% identity (123/124 amino acids identical)
Human: 95% identity (118/124 amino acids identical)
~50-60% identity with GABA-A-R-Beta2 and -Beta3

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N96/55

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with GABA-A-R-Beta2 or GABA-A-R-Beta3

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

GABRB1

Official Name

GABRB1

Full Name

GABA(A)R, Beta1

Alternative Names

Gamma-Aminobutyric Acid Type A Receptor Beta1 Subunit; Gamma-Aminobutyric Acid (GABA) A Receptor; Beta 1; Gamma-Aminobutyric Acid Receptor Subunit Beta-1; GABA(A) Receptor Subunit Beta-1; GABA(A) Receptor; Beta 1; EIEE45;