NeuroMab™ Anti-Histone H3 acetyl-Lys56 BBB Shuttle Antibody, Clone N307/12

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-HISTIH3J BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 51-60 (EIRRYQ[acetyl-K]STE) of human Histone H3.1 (also known by many other names, accession number P68431)
Mouse: 100% identity (10/10 amino acids identical)
Rat: 100% identity (10/10 amino acids identical)
100% identity with Histones H3.2, H3.3 and H3.3C

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N307/12

Applications

DB; IP

Application Notes

Reacts preferentially with Histone H3 acetylatedLys56 than with unacetylated-Lys56 or with other H3 acetylated-Lys epitopes (Lys4, Lys9, Lys14, Lys18, Lys23, Lys27, Lys36 and Lys64)

Research Areas

Epigenetics

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

HISTIH3J

Official Name

HISTIH3J

Full Name

Histone H3-acetyl-Lys56

Alternative Names

Histone H3-pThr11

Uniprot ID

P68431

Product Pictures

Fig. 1 Serial dilutions of BSA-conjugated modified and unmodified peptides dotted onto membrane and probed with N307/12 TC supe (left) and a rabbit polyclonal control (right).

Publications