NeuroMab™ Anti-Pancortin BBB Shuttle Antibody, Clone K96/7

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Noelin BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide of amino acids 131-150 of human Pancortin (GLESKFKQVEE SHKQHLARQ, also known as Noelin, Neuronal olfactomedin-related ER localized protein, Noe1, Noel, Noel1, Olfactomedin-1, Olfm1, 1B426B and D2Sut1e, accession number Q99784)
Mouse: 95% identity (19/20 amino acids)
Rat: 95% identity (19/20 amino acids)
100% identity with isoforms Pancortin-2, Pancortin-3 and Pancortin-4
<50% identity with Noelin-2 or Noelin-3

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

K96/7

Applications

WB; IHC; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Noelin

Official Name

OLFM1

Full Name

Pancortin

Alternative Names

OLFM1; AMY; NOE1; NOELIN1; OlfA; olfactomedin 1

Uniprot ID

Q99784

Product Pictures

Fig. 1 Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with K96/7 (left) or N52A/42 (right) TC supe.