NeuroMab™ Anti-Sortilin Antibody, Clone S-49

Product Overview

Description

The antibody specifically binds one or more epitopes within a sortilin protein, e.g., human sortilin or a mammalian sortilin. The anti-sortilin antibody has a property selected from the group consisting of: increasing extracellular levels of progranulin; increasing cellular levels of progranulin; decreasing cellular levels of sortilin; inhibiting interaction between sortilin and progranulin.

Species Reactivity

Human; Mammalian

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG

Clone Number

S-49

Applications

ELISA; Inhib; In Vitro; In Vivo; Antagonist

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

Sortilin

Alternative Names

SORT1; Gp95; LDLCQ6; NT3; NTR3; Sortilin 1

Product Pictures

Inhib

Figure 1 shows the dose-dependent inhibition of biotinylated progranulin binding to soltilin-expressing cells by anti-soltilin antibodies.

Inhib

Figure 2 shows the cell surface expression levels of saltylin after 72 hours of incubation with anti-saltillin antibody.

Inhib

Figure 3 shows the measurement of mouse progranulin (PGRN) protein levels in mouse plasma samples at different times after injection of anti-saultyrin antibody.