NeuroMab™ Anti-SVOP BBB Shuttle Antibody, Clone N356/9

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-SVOP BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-85 (MEEDLFQLRQLPVVKFRRTGESARSEDDAASGEHDVQIEGVRV GLEAVELDDGAAVPKEFANPTDDTFMVEDAVEAIGFGRFQWK, cytoplasmic N-terminus) of rat SVOP (also known as Synaptic vesicle 2-related protein and SV2-related protein, accession number Q9Z2I7)
Mouse: 97% identity (83/85 amino acids identical)
Human: 95% identity (81/85 amino acids identical)
<20% overall identity with SVOPL/SVOP2 but>80% identity (14/16 amino acids) near C-terminus (TFMVEDAVEAIGFGRF)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

N356/9

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with SVOPL/SVOP2

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

SVOP

Official Name

SVOP

Full Name

SVOP

Alternative Names

Synaptic vesicle (SV) 2 -related protein

Uniprot ID

Q9Z2I7

Product Pictures

Fig. 1 Transfected cell immunofluorescence: COS cells expressing GFP-tagged SVOP (left) and SVOPL/SVOP2 (right). Red=N356/9, Green=GFP, Blue=Hoechst nuclear stain.

Fig. 2 Immunoblot versus crude membranes from adult rat brain (RBM) and WT and SVOP KO mouse brains probed with N356/9 (left) and N52A/42 (right) TC supe.