NeuroMab™ Mouse Anti-Human APP 573-596 Monoclonal Antibody (CBP2477)

Product Overview

Description

Gemin 3, also known as DEAD-box helicase 20 (DDX20), is a putative RNA helicase that contains a conserved ASP-GLU-ALA-ASP (DEAD) motif. Gemin 3 is involved in a variety of cellular processes including initiation of protein translation, ribosome assembly, and alteration of RNA secondary structure. Gemin 3 is one of the core components of the survival of motor neurons (SMN) macromolecule protein complex, which plays an important role in the assembly and re-structuring of small nucleoproteins and transcriptosomes. Gemin 3 may also be involved in cancer as it acts as a tumor suppressor in hepatocellular carcinoma, and as a tumor promoter in breast cancer and prostate cancer2.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP2477

Applications

Application Notes

WB (0.2-1.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1813

Product Properties

Form

Liquid

Formulation

This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.

Handling Advice

Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

APP 573-596

Official Name

Gemin 3

Full Name

DDX20

Alternative Names

Probable ATP-dependent RNA helicase DDX20; also known as DEAD-box helicase 20 and gem-associated protein 3 (GEMIN3); is an enzyme that in humans is encoded by the DDX20 gene.

The DEAD box protein characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) is a putative RNA helicase. They are involved in many cellular processes involving changes in RNA secondary structure; such as translation initiation; nuclear and mitochondrial splicing; and ribosome and spliceosome assembly. Based on their distribution pattern; some members of this family are thought to be involved in embryogenesis; spermatogenesis; and cell growth and division. This gene encodes the DEAD box protein; which has ATPase activity and is an integral part of the survival of motor neuron (SMN) complexes. SMN is a gene product of spinal muscular atrophy; which may play a catalytic role in the function of SMN complex on RNP.