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Creative Biolabs

NeuroMab™ Rat Anti-Trem-1 Monoclonal Antibody (CBP2592)

[CAT#: NAB2007FY1113]

Rat Monoclonal [NSB8.2A12.3A12] to Trem-1

Host Species:
Rat
Species Reactivity:
Mouse
Applications:
FC

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Product Overview

Description

Rat anti-Mouse Trem-1 antibody, recognizes the mouse trigger receptor expressed on myeloid cell 1 (TREM-1), the immunoglobulin superfamily expressed on neutrophils The 30kD member and part of monocytes. TREM-1 is involved in the inflammatory response of microorganisms. Together with the adaptor protein DAP12, it activates neutrophils and monocytes, leading to the secretion of pro-inflammatory mediators and the enhancement of inflammatory response. Microbial infection also induces the release of a soluble form of TREM-1 from monocytes, which is reported to be an inhibitor of TREM-1.

Immunogen

Mouse TREM-1 Fc fusion protein.

Species Reactivity

Mouse

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG2a

Clone Number

CBP2592

Applications

FC

Application Notes

FC: 1/10

Relevant Diseases

Alzheimer's Disease; Neurodegenerative Disease

Research Areas

Neuroregeneration

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1885
Product Properties

Form

Liquid

Formulation

PBS, 0.09% Sodium Azide, 1% BSA

Preservatives

YES

Concentration

0.05 mg/ml

Purification

Protein G

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.

Research Use Only

For research use only, not for diagnostic or therapeutic use.
Target

Target

TREM1

Official Name

TREM1

Full Name

TREM1 Gene(Protein Coding) Triggering Receptor Expressed On Myeloid Cells 1

Alternative Names

Triggering Receptor Expressed On Myeloid Cells 1; Triggering Receptor Expressed On Monocytes 1; TREM-1; CD354 Antigen; CD354;

Gene ID

54210(Human); 58217(Mouse); 301229(Rat)

Uniprot ID

Q9NP99(Human); Q9JKE2(Mouse)
References

1. Wang, F. et al. (2012) Blocking TREM-1 signaling prolongs survival of mice with Pseudomonas aeruginosa induced sepsis.
Publications

Publications (0)

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