NeuroMab™ Mouse Anti-Human Desmoglein-1 Monoclonal Antibody (CBP4298)

[CAT#: NAB210169LS]

Anti-Desmoglein-1 Monoclonal Antibody

Host Species:: Mouse

Species Reactivity:: Human

Applications:: WB

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Product Overview

Description

Desmoglein 2 (DSG2) is a calcium-binding adhesion molecule that is highly expressed in epithelial cells and cardiomyocytes in vertebrates. DSG2 mainly locates to the intracellular adhesive junction called desmosome, which is a structure that functions in cell-to-cell adhesion. Clinically, mutations in DSG2 are mostly linked to cardiomyopathy. A recent GWAS study has shown that DSG2 is 1 of the 20 genetic risk factors that are associated with Alzheimer's disease.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP4298

Applications

Application Notes

WB (0.5-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 2305

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.