Mouse Anti-RBFOX1 Monoclonal Antibody (CBP4301)

Product Overview

Description

Rbfox1 is a member of the RNA binding protein family that shares a conservative RNA recognition motif. Rbfox1 has been shown to modulate alternative splicing by binding the consensus RNA sequence motif (U)GCAUG within introns. The interaction between cytoplasmic Rbfox1 and mRNA affects mRNA stability and translation. The binding of Rbfox1 protein to the C-terminus of ataxin-2 may be a contributing factor to the development of spinocerebellar ataxia type 2 .

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP4301

Applications

IHC-P

Application Notes

IHC-P (5.0-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Alexa Fluor 488

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

RBFOX1

Official Name

RBFOX1

Full Name

Fox-1 homolog A

Alternative Names

RBFOX1; 2BP1; A2BP1; FOX-1; FOX1; HRNBP1; RNA binding protein; fox-1 homolog 1; RNA binding fox-1 homolog 1

Gene ID

948

Uniprot ID

Q9NWB1 (Human); Q9JJ43 (Mouse)

References

1. Wang ET, et al. 2016. J. Neurosci. 36(45):11418
2. Duan W, et al. 2016. Mol Neurobiol. 53(3):1637
3. Kuroyanagi H, 2009. Cell Mol Life Sci. 66(24):3895

Publications