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Cells

Cellular models are indispensable in the realm of neuroscience research, offering benefits such as cost-efficiency, easy access, adaptability, and reliable reproducibility. These models serve as in vitro tools for delving into the complexities of cellular dynamics, elucidating the underlying mechanisms, and devising potential therapeutic strategies for neurological disorders.

Creative Biolabs is passionate about offering a broad of reliable and high-quality cell products derived from different species (human, mouse, rat, monkey, rabbit, etc.). We also offer specialized cell culture media and reagents to support your neural cell-based assays in neuroscience research and drug discovery. Our devoted team is steadfast in their commitment to furnish innovative solutions that cater to the requirements of scientists and researchers in the field. Collaborate with Creative Biolabs to access state-of-the-art cell models and resources for your research endeavors.

By Cell Categories

With advanced technologies and stringent standard of quality control, we offer a range of cell products to support your research more cost-effectively. Whether for drug discovery, disease modeling or basic research, our diverse cell repository provides the flexibility and versatility needed to advance scientific knowledge and discovery.

Fig 1: Primary rat olfactory ensheathing cells. (From previous orders supplied by Chinese suppliers)
Primary Cells
Maintain the characteristics and functions of the origin of the tissues. 		Fig 2: Immortalized brain microvascular endothelial cell line hCMEC/D3. (Wasielewska, 2020)
Immortalized Cell Lines
Proliferate indefinitely with features close to primary cells. 		Fig 3: Human ipsc and ipsc-derived neural cells. (Barak, 2022)
iPSC and iPSC-derived Cells
Powerful cell models from normal and disease donors.
Fig 4: Image of cultured GL261 cell line from our US lab.
Cell Lines
More easily transfected compared to primary neural cells and proliferate. 		Fig 5: Cell lysate are obtained from primary human Schwann cells. (Made by CHZ)
Cell Lysates
Ready to use, convenient and cost effective.

By Cell Types

We are proud to offer dozens of cell types, including but not limited to central and peripheral nerve cells. Each cell type is meticulously characterized and quality-tested to ensure reliability and consistency in research and experimentation.

Fig 6: Astrocyte morphology and structure. (Cabral, 2023)
Astrocytes 		Fig 7: Neuron morphology and structure. (Barak, 2022)
Neurons 		Fig 8: Microglia morphology and structure. (Barak, 2022)
Microglia 		Fig 9: Image of primary cultured neural stem cells. (Zhang, 2020)
Neural Stem Cells
Fig 10: The expression of nestin in ReNcell VM. (Yip, 2020)
Neural Progenitor Cells 		Fig 11: Oligodendrocyte morphology and structure. (Plastini, 2022)
Oligodendrocytes (OPC) 		Fig 12: Schwann cell morphology. (Milichko, 2020)
Schwann Cells 		Fig 13: The blood–brain barrier (BBB) consists of brain microvascular endothelial cells, brain vascular pericytes, and astrocytes; together they are known as the neurovascular unit (NVU). (Alcendor, 2019)
BBB-related Cells
Fig 14: Structure of meninges in homeostatic brain. (Su, 2023)
Meningeal Cells 		Fig 15: Internal structure of human eyeball. (Kanamaru, 2021)
Visual System-related Cells 		Fig 16: Diagram of the main sources of human dental tissue-derived mesenchymal stem cells. (Rodas-Junco, 2017)
Tooth-related Cells 		Fig 17: Schematic diagram of the olfactory system. (Kim, 2022)
Olfactory System-related Cells
Fig 18: Primary tumor cells. (Shi, 2023)
Tumor Cells 		Fig 19: Structure of satellite glial cells.
Other Glial Cells 		Other Cells

By Neurological Disease Models

We offer a range of verified cell models specifically used for neurological disease research. Our in vitro models encompass a wide range of neurological conditions to support diverse research needs.

AD-related Cells Fig 20: AD is characterised by the inclusion of misfolded amyloid-β (Aβ) and neurofibrillary tangles in pyramidal neurons, primarily in the hippocampus and cortex regions of the brain. (Amartumur, 2024)
PD-related Cells Fig 21: PD is characterised by Lewy body aggregates composed of misfolded α-synuclein and degeneration of dopaminergic neurons in the substantia nigra region of the brain. (Amartumur, 2024)
HD-related Cells Fig 22: HD is characterized by including mutant Huntingtin protein (mHTT) and degeneration of medium spiny neurons in the basal ganglia, and corpus striatum of the brain. (Amartumur, 2024)
ALS-related Cells Fig 23: ALS is characterised by including mutant TAR DNA-binding protein 43 (TDP-43) and other proteins, degeneration of motor neurons in the motor cortex and spinal cord, and muscle atrophy with dysfunctional proteins. (Amartumur, 2024)
Epilepsy-related Cells Fig 24: Interconnected mechanisms of epilepsy involving OS. (Parsons, 2022) Brain Tumor-related Cells Fig 25: Main brain tumors. (Antonica, 2022)

We also provide custom primary cell isolation services, cell immortalization services, cell line development service and cell-based assay to meet your specific scientific needs by integrating cutting-edge technologies and adhering to strict standards of quality control. Please feel free to contact us to speed up your research progress.

References

  1. Wasielewska, Joanna M et al. "Modeling the Blood–Brain Barrier to Understand Drug Delivery in Alzheimer's Disease." Alzheimer's Disease: Drug Discovery. 2020, Dec 18. Chapter 7
  2. Barak, M et al. "Human iPSC-Derived Neural Models for Studying Alzheimer's Disease: from Neural Stem Cells to Cerebral Organoids." Stem Cell Rev and Rep. 2022, 18(2):792-820.
  3. Cabral-Costa, João Victor, and Alicia J Kowaltowski. "Mitochondrial Ca2+ handling as a cell signaling hub: lessons from astrocyte function." Essays Biochem. 2023, 67(1):63-75.
  4. Zhang, Yi et al. "Maternal sevoflurane exposure affects differentiation of hippocampal neural stem cells by regulating miR-410-3p and ATN1." Stem Cell Res Ther. 2020, 11(1):423.
  5. Yip, Jackson L K et al. "AGS3 and Gαi3 Are Concomitantly Upregulated as Part of the Spindle Orientation Complex during Differentiation of Human Neural Progenitor Cells." Molecules. 2020, 25(21):5169.
  6. Plastini, Melanie J et al. "Transcriptional abnormalities in induced pluripotent stem cell-derived oligodendrocytes of individuals with primary progressive multiple sclerosis." Front Cell Neurosci. 2022, 16:972144.
  7. Milichko, Valentin, and Vyacheslav Dyachuk. "Novel Glial Cell Functions: Extensive Potency, Stem Cell-Like Properties, and Participation in Regeneration and Transdifferentiation." Front Cell Dev Biol. 2020, 8:809.
  8. Alcendor, Donald J. "Human Vascular Pericytes and Cytomegalovirus Pathobiology." Int J Mol Sci. 2019, 20(6):1456.
  9. Su, Yun et al. "Meningeal immunity and neurological diseases: new approaches, new insights." J Neuroinflammation. 2023, 20(1):125.
  10. Kanamaru, Manami et al. "Simulation-Based Clarification of Appropriate Factors for Presenting Phosphene in Two Directions Avoiding Electrical Interference." Bioengineering (Basel). 2021, 8(8):111.
  11. Rodas-Junco, Beatriz A et al. "Stem Cells from Dental Pulp: What Epigenetics Can Do with Your Tooth." Front Physiol. 2017, 8:999.
  12. Kim, Chuntae et al. "Artificial olfactory sensor technology that mimics the olfactory mechanism: a comprehensive review." Biomater Res. 2022, 26(1):40.
  13. Shi, Zhen-Duo et al. "Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies." Signal Transduct Target Ther. 2023, 8(1):113.
  14. Andreeva, Daria et al. "Satellite Glial Cells: Morphology, functional heterogeneity, and role in pain." Front Cell Neurosci. 2022, 16:1019449.
  15. Amartumur, S et al. "Neuropathogenesis-on-chips for neurodegenerative diseases." Nature Communications. 2024, 15(2219).
  16. Parsons, Anna L M et al. "The Interconnected Mechanisms of Oxidative Stress and Neuroinflammation in Epilepsy." Antioxidants (Basel). 2022, 11(1):157.
  17. Antonica, Francesco et al. "Modeling Brain Tumors: A Perspective Overview of in vivo and Organoid Models." Front Mol Neurosci. 2022, 15:818696.
For Research Use Only. Not For Clinical Use.

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