Product
Human CHO-K1/GLP1R/Gα15 Stable Cell Line
[CAT#: NCL20120065CR]
Glucagon-like Peptide 1 Receptor Stable Cell Line
- Species:
- Human
- Applications:
- GPCR Screening
- Cell Types:
- CHO-K1; GPCR Cell
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Product Overview
Description
GLP1R binds specifically the glucagon-like peptide-1 (GLP1) and has much lower affinity for related peptides such as the gastric inhibitory polypeptide and glucagon. GLP1R is known to be expressed in pancreatic beta cells. Activated GLP1R stimulates the adenylyl cyclase pathway which results in increased insulin synthesis and release of insulin. Consequently, GLP1R has been suggested as a potential target for the treatment of diabetes. GLP1R is also expressed in the brain where it is involved in the control of appetite. Furthermore, mice which over express GLP1R display improved memory and learning.
Cell Types
CHO-K1; GPCR Cell
Applications
GPCR Screening
Research Areas
GPCR
Species
Human
Properties
Size
>1x10^6 Cells
Form
Frozen cells
Culture Medium
Ham's F12, 10% FBS, 200 μg/ml Zeocin, 100 μg/ml Hygromycin B
Freeze Medium
45% culture medium, 45% FBS, 10% DMSO
Receptor
GLP1R
Family
Glucagon receptor
Strain
GLP1R/Gα15 Cell Line
Cell Purity
>95%
Shipping
Dry ice
Storage
Liquid nitrogen immediately upon delivery
Handling Advice
Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
repeated exposure.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Warnings
Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.
Target Details
References
1. Kim, M., Tan, Y. S., Cheng, W. C., Kingsbury, T. J., Heimfeld, S., & Civin, C. I. (2015). MIR 144 and MIR 451 regulate human erythropoiesis via RAB 14. British journal of haematology, 168(4), 583-597. 2. Hildebrand, M. S., Phillips, A. M., Mullen, S. A., Adlard, P. A., Hardies, K., Damiano, J. A.,.. & Hendrickx, R. (2015). Loss of synaptic Zn 2+ transporter function increases risk of febrile seizures. Scientific reports, 5, 17816.
Publications
Publications (0)
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
