Product
NeuroMab™ Anti-EAAC1 BBB Shuttle Antibody, Clone N420/24
[CAT#: NRZP-0423-ZP98]
- Species Reactivity:
- Rat; Mouse; Human
- Applications:
- WB; IHC; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-EAAT3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 115-208 (extracellular domain) of rat EAAC1 (also known as Excitatory amino-acid carrier 1, Excitatory amino acid transporter 3, Neuronal and epithelial glutamate transporter, Sodium-dependent glutamate/aspartate transporter 3, Solute carrier family 1 member 1, Eaat3 and Slc1a1, accession number P51907)
Mouse: 94% identity (89/94 amino acids identical)
Human: 84% identity (80/95 amino acids identical)
<50% identity with GLT1/EAAT2/SLC1A2
Mouse: 94% identity (89/94 amino acids identical)
Human: 84% identity (80/95 amino acids identical)
<50% identity with GLT1/EAAT2/SLC1A2
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Rat; Mouse; Human
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
N420/24
Applications
WB; IHC; ICC
Research Areas
Transporters
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
EAAT3
Official Name
SLC1A1
Full Name
EAAC1
Alternative Names
SLC1A1; EAAC1; EAAT3; SCZD18; DCBXA; solute carrier family 1 member 1
Uniprot ID
P51907
Product Pictures
IB
Fig. 1 Adult rat brain membrane immunoblot.
Publications
Publications (0)
Neural Cell Lines
Neural Antibodies
For Research Use Only. Not For Clinical Use.
