NeuroMab™ Anti-EPHA2 BBB Shuttle Antibody(NRZP-1022-ZP3873)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

Inhib; In Vitro; Agonist

Relevant Diseases

Glioblastoma Multiforme

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

EPHA2

Official Name

EPHA2

Full Name

EPH receptor A2 (ephrin type-A receptor 2)

Alternative Names

EPHA2; Epha2; AW545284; Eck; Myk2; Sek-2; Sek2; ARCC2; CTPA; CTPP1; CTRCT6; EPH receptor A2; ECK

Product Pictures

Figure 1 Isothermal titration calorimetry (ITC) curves of binding between 135G3 and EphA2-LBD (AH = -21.9 kcal/mol, -TAS = 13.5 kcal/mol) and EphA4-LBD (no significant binding).