NeuroMab™ Anti-Gamma-protocadherin-C3 BBB Shuttle Antibody, Clone N174B/27

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-PCDHGC3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 720-804 (variable cytoplasmic domain) of mouse Gammaprotocadherin-C3 (also known as PCDH-gamma-C3, Protocadherin-43, PC-43, Protocadherin-2 and PCDH2, accession number Q91XX1)
Human: 97% identity (83/85 amino acids identical)
Rat: 97% identity (83/85 amino acids identical)
No significant identity with other Gamma-protocadherin proteins

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N174B/27

Applications

WB; IHC; ICC

Application Notes

No cross-reactivity against other Gamma-protocadherin-A, -B or -C proteins

Research Areas

CAMs

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

PCDHGC3

Official Name

PCDHGC3

Full Name

Gamma-protocadherin-C3

Alternative Names

PCDHGC3; PC43; PCDH-GAMMA-C3; PCDH2; protocadherin gamma subfamily C; 3

Uniprot ID

Q91XX1

Product Pictures

Fig. 1 Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged Gammaprotocadherin-C3 and–A3 and untagged Kv2.1 plasmids and probed with N174B/27 (left) and N159/5 (right) TC supe.

Publications