NeuroMab™ Anti-KCNT1/Slo2.2/Slack K+ channel BBB Shuttle Antibody, Clone N3/26

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNT1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1168-1237 (cytoplasmic C-terminus) of rat Slo2.2 (also known as Potassium channel subfamily T member 1, Sequence like a calcium-activated potassium channel subunit, Kcnt1, KCa4.1, Kiaa1422 and Slack, accession number Q9Z258)
Mouse: 98% identity (69/70 amino acids identical)
Human: 94% identity (66/70 amino acids identical)
~60% identity with KCNT2/Slo2.1/Slick

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N3/26

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with KCNT2/Slo2.1/Slick

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCNT1

Official Name

KCNT1

Full Name

KCNT1/Slo2.2/Slack K+ channel

Alternative Names

KCNT1; EIEE14; ENFL5; KCa4.1; SLACK; bA100C15.2; Slo2.2; potassium sodium-activated channel subfamily T member 1

Uniprot ID

Q9Z258

Product Pictures

Fig. 1 Immunoblot against brain membranes from adult rat (RBM), mouse (MBM) or human cerebral cortex [HBM(Cx)] or hippocampus [HBM(H)] probed with N3/26 (left) or N52A/42 (right) TC supe.

Fig. 2 Immunoblot against brain membranes from adult rat (RBM), Slo2.2 knockout (MBM-Slo2.2 KO) or wild-type (MBM-WT) mice probed with N3/26 (left) or N52A/42 (right) TC supe.