Product
NeuroMab™ Anti-KCNT1/Slo2.2/Slack K+ channel BBB Shuttle Antibody, Clone N3/26
[CAT#: NRZP-0423-ZP188]
- Species Reactivity:
- Rat; Mouse; Human
- Applications:
- WB; IHC; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNT1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 1168-1237 (cytoplasmic C-terminus) of rat Slo2.2 (also known as Potassium channel subfamily T member 1, Sequence like a calcium-activated potassium channel subunit, Kcnt1, KCa4.1, Kiaa1422 and Slack, accession number Q9Z258)
Mouse: 98% identity (69/70 amino acids identical)
Human: 94% identity (66/70 amino acids identical)
~60% identity with KCNT2/Slo2.1/Slick
Mouse: 98% identity (69/70 amino acids identical)
Human: 94% identity (66/70 amino acids identical)
~60% identity with KCNT2/Slo2.1/Slick
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Rat; Mouse; Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
N3/26
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with KCNT2/Slo2.1/Slick
Research Areas
K+ channels
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
KCNT1
Official Name
KCNT1
Full Name
KCNT1/Slo2.2/Slack K+ channel
Alternative Names
KCNT1; EIEE14; ENFL5; KCa4.1; SLACK; bA100C15.2; Slo2.2; potassium sodium-activated channel subfamily T member 1
Uniprot ID
Q9Z258
Product Pictures
IB
Fig. 1 Immunoblot against brain membranes from adult rat (RBM), mouse (MBM) or human cerebral cortex [HBM(Cx)] or hippocampus [HBM(H)] probed with N3/26 (left) or N52A/42 (right) TC supe.
IB
Fig. 2 Immunoblot against brain membranes from adult rat (RBM), Slo2.2 knockout (MBM-Slo2.2 KO) or wild-type (MBM-WT) mice probed with N3/26 (left) or N52A/42 (right) TC supe.
IHC
Fig. 3 Adult rat hippocampus CA1 immunohistochemistry.
IHC
Fig. 4 Adult rat medial vestibular nucleus and trapezoid body immunohistochemistry.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
