NeuroMab™ Anti-Kir6.1 potassium channel BBB Shuttle Antibody, Clone N366/60
[CAT#: NRZP-0423-ZP197]
- Species Reactivity:
- Rat; Mouse
- Applications:
- WB; IHC; ICC
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNJ8 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 306-424 (cytoplasmic C-terminus) of rat Kir6.1 (also known as ATPsensitive inward rectifier potassium channel 8, Potassium channel inwardly rectifying subfamily J member 8, uKATP-1 and Kcnj8, accession number Q63664)
Mouse: 99% identity (118/119 amino acids identical)
Human: 96% identity (115/119 amino acids identical)
<50% identity with Kir6.2
Mouse: 99% identity (118/119 amino acids identical)
Human: 96% identity (115/119 amino acids identical)
<50% identity with Kir6.2
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Rat; Mouse
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
N366/60
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with Kir6.2
Research Areas
K+ channels
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
KCNJ8
Official Name
KCNJ8
Full Name
Kir6.1 K+ channel
Alternative Names
KCNJ8; KIR6.1; uKATP-1; potassium voltage-gated channel subfamily J member 8; potassium inwardly rectifying channel subfamily J member 8
Uniprot ID
Q63664
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
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