NeuroMab™ Anti-Kir6.1 potassium channel BBB Shuttle Antibody, Clone N366/60

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNJ8 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 306-424 (cytoplasmic C-terminus) of rat Kir6.1 (also known as ATPsensitive inward rectifier potassium channel 8, Potassium channel inwardly rectifying subfamily J member 8, uKATP-1 and Kcnj8, accession number Q63664)
Mouse: 99% identity (118/119 amino acids identical)
Human: 96% identity (115/119 amino acids identical)
<50% identity with Kir6.2

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N366/60

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with Kir6.2

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCNJ8

Official Name

KCNJ8

Full Name

Kir6.1 K+ channel

Alternative Names

KCNJ8; KIR6.1; uKATP-1; potassium voltage-gated channel subfamily J member 8; potassium inwardly rectifying channel subfamily J member 8

Uniprot ID

Q63664

Product Pictures

Fig. 1 Immunoblot against extracts of COS cells transiently transfected with Myc-tagged Kir6.1, HAtagged Kir6.2 or untagged Kv2.1 plasmid probed with N366/60 (left) or N52A/42 (right) TC supe.