NeuroMab™ Anti-Kv3.4 potassium channel BBB Shuttle Antibody, Clone N72/16

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNC4 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 175-192 (GDEAGDDERELALQRLGP, cytoplasmic Nterminus) of rat Kv3.4 (also known as Potassium voltage-gated channel subfamily C member 4, Voltage-gated potassium channel subunit Kv3.4, Kcnc4, KSHIIIC and Raw3, accession number Q63734) Mouse: 100% identity (18/18 amino acids identical)
Human: 94% identity (17/18 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N72/16

Applications

WB; IHC; IP; ICC

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCNC4

Official Name

KCNC4

Full Name

Kv3.4 K+ channel

Alternative Names

Potassium Voltage-Gated Channel Subfamily C Member 4; Potassium Channel; Voltage Gated Shaw Related Subfamily C; Member 4; Potassium Voltage-Gated Channel; Shaw-Related Subfamily; Member 4; C1orf30; KSHIIIC; Voltage-Gated Potassium Channel Subunit KV3.4;