NeuroMab™ Anti-MFF BBB Shuttle Antibody, Clone N382/14

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-MFF BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-173 and 272-322 of mostly human MFF (also known as Mitochondrial fission factor, C2orf33, AD030, AD033 and GL004, accession number Q9GZY8)
Human: 96% identity (167/173 amino acids identical) and 94% identity (48/51 amino acids identical)
Rat: 95% identity (141/147 amino acids identical) and 92% identity (47/51 amino acids identical)
Mouse: 93% identity (138/147 amino acids identical) and 84% identity (43/51 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N382/14

Applications

WB; IHC; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

MFF

Official Name

MFF

Full Name

MFF

Alternative Names

MFF; C2orf33; GL004; mitochondrial fission factor; EMPF2

Uniprot ID

Q9GZY8

Product Pictures

Fig. 1 Immunoblot against crude extracts of COS cells transiently transfected with GFP-tagged MFF, MFFexon1 or untagged Kv2.1 plasmid, adult rat brain membranes (RBM) or MFF wild-type (WT) or knockout (KO) mouse embryonic fibroblast cells probed with N382/14 TC supe.

Fig. 2 Immunoblot against crude extracts of COS cells transiently transfected with GFP-tagged MFF, MFFexon1 or untagged Kv2.1 plasmid, adult rat brain membranes (RBM) or MFF wild-type (WT) or knockout (KO) mouse embryonic fibroblast cells probed withrabbit polyclonal TC supe.

Fig. 3 Immunoblot against crude extracts of COS cells transiently transfected with GFP-tagged MFF, MFFexon1 or untagged Kv2.1 plasmid, adult rat brain membranes (RBM) or MFF wild-type (WT) or knockout (KO) mouse embryonic fibroblast cells probed with N52A/42 TC supe.