NeuroMab™ Anti-SEZ6 Antibody(NRP-0422-P517)
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat; Cynomolgus Monkey
- Applications:
- FC; IHC; In Vitro; In Vivo
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
The antibody specifically binds to a human SEZ6 protein, use for the treatment, diagnosis or prophylaxis of neoplastic disorders.
Species Reactivity
Human; Mouse; Rat; Cynomolgus Monkey
Clonality
Monoclonal
Host Species
Mouse
Applications
FC; IHC; In Vitro; In Vivo
Relevant Diseases
Epilepsy
Product Properties
Formulation
PBS only
Preservatives
BSA Free
Concentration
1mg/mL
Purification
Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line
Purity
>95% by SDS PAGE or HPLC
Endotoxin Level
Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg
Low Endotoxin < 1 EU/mg
Shipping
Gel Packs
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Research Use Only
For research use only
Target
Product Pictures
FuncS
Figure 1 shows SEZ6 expression in HEK-293T cells modified to overexpress human SEZ6 protein (h293T-HuSEZ6) using the anti-SEZ6 antibody SC17.33.
Axis corresponds to concentration of 3E antibody (Fab) and Y axis corresponds to NGF binding (percentage of maximal UR). Increasing concentrations of Fab E3 blocked the interaction of NGF with p75 and trkA, as indicated by a decrease in signal (measured in UR). When the concentration of E3 antibody (Fab) was equal to that of NGF, no NGF binding was observed (indicated by zero signal).
Publications
Publications (0)
Neural Antibodies
Scientific Resources
Customer Reviews and Q&As
Customer Reviews
Average Customer Ratings
Overall
5.0
ExcellentGreat performance in flow cytometryI've been using the antibody for flow cytometry, and it consistently delivers reliable results. The specificity is top-notch, and the signal is strong with minimal background noise. This antibody has become a staple in my lab for immune checkpoint studies.
ExcellentHighly specific antibodyI’ve tested several antibodies for PVRIG detection, and this one from NeuroMab is by far the best. It binds specifically to the target protein with excellent sensitivity
ExcellentGood signal with minimal backgroundIn my immunohistochemistry experiments, this antibody provided a good signal with minimal background staining. The clarity and precision in detecting PVRIG in tissue sections were impressive. I’m very satisfied with its performance.
ExcellentPerfect for fow cytometry applicationsI have used this antibody in several flow cytometry experiments, and it has consistently performed well. The binding affinity is excellent, and the results are reproducible.
ExcellentExceptional quality and sensitivitThe quality and sensitivity of the antibody are exceptional. It has significantly improved the accuracy of my experiments, particularly in detecting low levels of PVRIG in complex samples.
Q&As
Can this antibody be used for immunohistochemistry on paraffin-embedded tissues?
Yes, the antibody is suitable for immunohistochemistry (IHC) on paraffin-embedded tissues. It has been optimized to work well with both frozen and formalin-fixed, paraffin-embedded (FFPE) tissue sections. The antibody provides strong, specific staining with minimal background, allowing for clear visualization of PVRIG in various tissue types.
What controls should I use when working with the antibody?
When working with the antibody, we recommend including both positive and negative controls in your experiments. For western blotting, use a lysate from a cell line known to express PVRIG as a positive control. For immunohistochemistry or flow cytometry, tissues or cells with confirmed PVRIG expression serve as good controls. Additionally, using a secondary antibody control can help identify any non-specific binding.
What type of secondary antibody is recommended for use with this product?
For optimal results, we recommend using a secondary antibody that is specific to the host species of the antibody, which is typically a mouse monoclonal antibody. A high-quality anti-mouse IgG secondary antibody, conjugated with a detection label such as HRP for western blotting or a fluorophore for immunofluorescence, will provide the best results. The choice of detection label depends on your specific application.
For Research Use Only. Not For Clinical Use.
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